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. 2013 Jan;24(1):238-44.
doi: 10.1093/annonc/mds287. Epub 2012 Aug 16.

Dietary glycemic load, glycemic index, and carbohydrates on the risk of primary liver cancer among Chinese women and men

E Vogtmann  1 , H L Li, X O Shu, W H Chow, B T Ji, H Cai, J Gao, W Zhang, Y T Gao, W Zheng, Y B Xiang
Affiliations

Dietary glycemic load, glycemic index, and carbohydrates on the risk of primary liver cancer among Chinese women and men

E Vogtmann et al. Ann Oncol. 2013 Jan.

Abstract

Background: Dietary glycemic index (GI) and glycemic load (GL) typically have a positive relationship with obesity and diabetes, which are risk factors for liver cancer. However, studies on their association with liver cancer have yielded inconsistent results. Therefore, we assessed the association of GI, GL, and carbohydrates with liver cancer risk.

Patients and methods: A total of 72 966 women and 60 207 men from the Shanghai Women's Health Study (SWHS) and the Shanghai Men's Health Study (SMHS) were included for analysis. Food frequency questionnaire (FFQ) data were used to calculate daily dietary GI, GL, and carbohydrate intake. These values were energy adjusted and categorized into quintiles. The hazard ratios (HRs) and 95% confidence intervals (CI) were calculated with adjustment for potential confounders.

Results: After a median follow-up time of 11.2 years for the SWHS and 5.3 years for the SMHS, 139 and 208 incident liver cancer cases were identified in the SWHS and SMHS, respectively. In multivariable Cox regression models, no statistically significant trends by quintile of GI, GL, or carbohydrate intake were observed. Stratification by chronic liver disease/hepatitis, diabetes, or body mass index (BMI) did not alter the findings.

Conclusions: There is little evidence that dietary GI, GL, or carbohydrates affect the incidence of liver cancer in this Asian population.

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References

    1. Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. In. Lyon, France: International Agency for Research on Cancer; 2010.
    1. Chen JG, Zhang SW. Liver cancer epidemic in China: past, present and future. Semin Cancer Biol. 2011;21:59–69. - PubMed
    1. Bouvard V, Baan R, Straif K, et al. A review of human carcinogens––Part B: biological agents. Lancet Oncol. 2009;10:321–322. - PubMed
    1. Baan R, Straif K, Grosse Y, et al. Carcinogenicity of alcoholic beverages. Lancet Oncol. 2007;8:292–293. - PubMed
    1. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 82 Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. In. Lyon, France: IARC Press and World Health Organization Marketing and Dissemination; 2002. - PMC - PubMed

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