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. 2012 Dec 30;200(2-3):1014-7.
doi: 10.1016/j.psychres.2012.07.002. Epub 2012 Aug 16.

Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia

Marco Ferrari  1 , Emilio Bolla, Paola Bortolaso, Camilla Callegari, Nicola Poloni, Sergio Lecchini, Simone Vender, Franca Marino, Marco Cosentino
Affiliations

Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia

Marco Ferrari et al. Psychiatry Res. .

Abstract

We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2(⁎)1C and (⁎)1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019).

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