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Comment
. 2012 Aug 17;150(4):667-8.
doi: 10.1016/j.cell.2012.07.027.

Contraception for men: a breakthrough new approach

Affiliations
Comment

Contraception for men: a breakthrough new approach

William J Bremner. Cell. .

Abstract

There has not been a new reversible contraceptive for men since the development of the condom, centuries ago. Matzuk et al. describe a new molecular approach using administration of a small molecule to directly and reversibly inhibit spermatogenesis in mice by blocking the function of a testicular bromodomain without apparent adverse effect on the organism or offspring.

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Comment on

  • Small-molecule inhibition of BRDT for male contraception.
    Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J, Knapp S, Bradner JE. Matzuk MM, et al. Cell. 2012 Aug 17;150(4):673-84. doi: 10.1016/j.cell.2012.06.045. Cell. 2012. PMID: 22901802 Free PMC article.

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