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. 2012 Aug 17;150(4):669-70.
doi: 10.1016/j.cell.2012.07.020.

Hippo signaling goes long range

Veronica A Codelia  1 , Kenneth D Irvine
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Free article
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Hippo signaling goes long range

Veronica A Codelia et al. Cell. .
Free article

Abstract

The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.

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