Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012:750:116-32.
doi: 10.1007/978-1-4614-3461-0_9.

Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses

Affiliations
Review

Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses

Claus H Nielsen et al. Adv Exp Med Biol. 2012.

Abstract

The role of naturally occurring autoantibodies (NAbs) in homeostasis and in disease manifestations is poorly understood. In the present chapter, we review how NAbs may interfere with the cytokine network and how NAbs, through formation of complement-activating immune complexes with soluble self-antigens, may promote the uptake and presentation of self-molecules by antigen-presenting cells. Both naturally occurring and disease-associated autoantibodies against a variety of cytokines have been reported, including NAbs against interleukin (IL)-1α, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor, interferon (IFN)-α, IFN-β, IFN-γ, macrophage chemotactic protein-1 and IL-21. NAbs against a variety of other self-antigens have also been reported, and using thyroglobulin as an example we discuss how NAbs are capable of promoting uptake of immune complexes via complement receptors and Fc-receptors on antigen-presenting cells and thereby regulate T-cell activity. Knowledge of the influence of NAbs against cytokines on immune homeostasis is likely to have wide-ranging implications both in understanding pathogenesis and in treatment of many immunoinflammatory disorders, including a number of autoimmune and autoinflammatory diseases.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Ochsenbein A.F., Fehr T., Lutz C., et al. Control of early viral and bacterial distribution and disease by natural antibodies. Science. 1999;286:2156–9. doi: 10.1126/science.286.5447.2156. - DOI - PubMed
    1. Grabar P. Hypothesis. Auto-antibodies and immunological theories: an analytical review. Clin Immunol Immunopathol. 1975;4:453–66. doi: 10.1016/0090-1229(75)90087-2. - DOI - PubMed
    1. Lutz H.U., Flepp R., Stringaro-Wipf G. Naturally occurring autoantibodies to exoplasmic and cryptic regions of band 3 protein, the major integral membrane protein of human red blood cells. J Immunol. 1984;133:2610–8. - PubMed
    1. Lutz H.U., Bussolino F., Flepp R., et al. Naturally occurring anti-band-3 antibodies and complement together mediate phagocytosis of oxidatively stressed human erythrocytes. Proc Natl Acad Sci USA. 1987;84:7368–72. doi: 10.1073/pnas.84.21.7368. - DOI - PMC - PubMed
    1. Bendtzen K., Svenson M., Jønsson V., et al. Autoantibodies to cytokines — friends or foes? Immunol Today. 1990;11:167–9. doi: 10.1016/0167-5699(90)90068-K. - DOI - PubMed

MeSH terms