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Editorial
. 2012 Aug 17;111(5):513-5.
doi: 10.1161/CIRCRESAHA.112.276063.

More than just an engine: the heart regulates body weight

Heinrich Taegtmeyer, Antony Rodriguez
Editorial

More than just an engine: the heart regulates body weight

Heinrich Taegtmeyer et al. Circ Res. .

Abstract

A recent study published in Cell may represent a paradigm shift in the way we look at cardiac metabolism: The study identifies the heart as an endocrine organ that regulates body weight. It raises two important questions: What would be the “slimming factor” released by the heart that regulates fuel homeostasis in distant organs? What are the possible mechanisms directing metabolic energy to either storage or dissipation?

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Figures

Figure
Figure
A putative cardiac “slimming factor” regulates body weight and systemic metabolism, possibly by substrate cycling. See text for details.
See this image and copyright information in PMC

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References

    1. Grueter CE, van Rooij E, Johnson BA, DeLeon SM, Sutherland LB, Qi X, Gautron L, Elmquist JK, Bassel-Duby R, Olson EN. A cardiac microrna governs systemic energy homeostasis by regulation of med13. Cell. 2012;149:671–683. - PMC - PubMed
    1. Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, Bayer M, Haschemi A, Puviindran V, Tar K, Orthofer M, Neely GG, Dietzl G, Manoukian A, Funovics M, Prager G, Wagner O, Ferrandon D, Aberger F, Hui CC, Esterbauer H, Penninger JM. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell. 2010;140:148–160. - PubMed
    1. Liu N, Olson EN. MicroRNA regulatory networks in cardiovascular development. Dev Cell. 2010;18:510–525. - PMC - PubMed
    1. Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ, Jr, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012;125:2751–2761. - PMC - PubMed
    1. van Rooij E, Purcell AL, Levin AA. Developing microRNA therapeutics. Circ Res. 2012;110:496–507. - PubMed