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Review
. 2013 Feb;24(1):51-7.
doi: 10.1016/j.cytogfr.2012.07.002. Epub 2012 Aug 18.

Emerging role of interleukin-22 in autoimmune diseases

Hai-Feng Pan  1 , Xiang-Pei Li, Song Guo Zheng, Dong-Qing Ye
Affiliations
Review

Emerging role of interleukin-22 in autoimmune diseases

Hai-Feng Pan et al. Cytokine Growth Factor Rev. 2013 Feb.

Abstract

Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the importance of IL-22 in host defense against Gram-negative bacterial organisms (in gut and lung). Recently, there is emerging evidence that IL-22 is involved in the development and pathogenesis of several autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's syndrome (SS) and psoriasis. Therapeutics targeting IL-22 therefore may have promise for treating various autoimmune diseases. In this review, we discuss the recent progression of the involvement of IL-22 in the development and pathogenesis of autoimmune diseases, as well as its clinical implications and therapeutic potential.

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Conflict of interest statement

Declaration of interest statement: None declared

Figures

Figure 1
Figure 1. Signaling pathways of IL-22
IL-22 binds as a homodimer at a receptor complex composed of the IL-10R2 and the IL-22R1. IL-22BPacts as a natural, soluble antagonist. Receptor signaling induces the phosphorylation of Jak-1 and Tyk-2, which activates the transcription factor STAT1, and depending on the cell type, also STAT3 and STAT5. MAPKpathway (including MEK1/2, ERK1/2, JNK, and p38) are also activated through a distinct pathway.
See this image and copyright information in PMC

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