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. 2012 Oct 7;48(77):9649-51.
doi: 10.1039/c2cc33359g.

Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Erin Wachter  1 , David K Heidary, Brock S Howerton, Sean Parkin, Edith C Glazer
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Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Erin Wachter et al. Chem Commun (Camb). .

Abstract

Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

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