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Editorial
. 2012 Sep;27(9):1412-4.
doi: 10.1111/j.1440-1746.2012.07196.x.

Beyond obesity: is cholesterol-induced liver injury the cause of non-alcoholic steatohepatitis?

George N Ioannou
Editorial

Beyond obesity: is cholesterol-induced liver injury the cause of non-alcoholic steatohepatitis?

George N Ioannou. J Gastroenterol Hepatol. 2012 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Unifactorial model of non-alcoholic steatohepatitis (NASH) with cholesterol-induced liver damage as the critical pathogenetic factor.
See this image and copyright information in PMC

Comment on

References

    1. Adams LA, Marsh JA, Ayonrinde OT, et al. Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity. J Gastroenterol Hepatol. 2012;27:1520–7. - PubMed
    1. Valenti L, Al-Serri A, Daly AK, et al. Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology. 2010;51:1209–17. - PubMed
    1. Savard C, Tartaglione EV, Kuver R, et al. Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. Hepatology. 2012 doi: 10.1002/hep.25800. [Epub ahead of print] - DOI - PMC - PubMed
    1. Subramanian S, Goodspeed L, Wang SA, et al. Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. J. Lipid Res. 2011;52(9):1626–35. - PMC - PubMed
    1. Van Rooyen DM, Larter CZ, Haigh WG, et al. Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis. Gastroenterology. 2011;141:1393–403. 1403 e1–5. - PMC - PubMed

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