Review
doi: 10.1016/j.micinf.2012.07.019.
Epub 2012 Aug 9.
Early secretory antigenic target-6 of Mycobacterium tuberculosis: enigmatic factor in pathogen-host interactions
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- PMID: 22909901
- DOI: 10.1016/j.micinf.2012.07.019
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Review
Early secretory antigenic target-6 of Mycobacterium tuberculosis: enigmatic factor in pathogen-host interactions
Microbes Infect.
2012 Nov.
Free article
Abstract
T helper (Th) 1 and 17 cells play important roles in host protective responses against tuberculosis. Early Secretory Antigenic Target 6; a Region of Difference 1 (RD1) encoded protein, mounts Th17-responses in the lung. Therefore, lack of RD-1 region makes Bacillus Calmette-Guérin (BCG) less vaccine efficacious than parent strains.
Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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