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Comment
. 2012 Sep;13(9):808-10.
doi: 10.1038/ni.2396.

Tumor immunity times out: TIM-3 and HMGB1

Daolin Tang, Michael T Lotze
Comment

Tumor immunity times out: TIM-3 and HMGB1

Daolin Tang et al. Nat Immunol. 2012 Sep.

Abstract

The characteristics of the tumor microenvironment vary widely. New work shows that after tumor-associated expression of the receptor TIM-3 by dendritic cells, TIM-3 inhibits the antitumor efficacy of DNA vaccines and chemotherapy by binding to the damage-associated molecular pattern molecule, HMGB1.

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
TIM-3 serves as a major regulator of immunity. (a) TIM-3 suppresses nucleic acid–mediated antitumor immune responses and promotes cancer immune escape by directly binding HMGB1. Blocking TIM-3 through the use of antibody to TIM-3 enhances the antitumor efficacy of DNA vaccines and a nonimmunogenic chemotherapeutic agent by acting on DCs in the tumor microenvironment (TADCs). mAb, monoclonal antibody; IFN, interferon. (b) Expression and function of TIM-3 in various cells of the immune system. TH1, T helper type 1; NK, natural killer.
See this image and copyright information in PMC

Comment on

References

    1. Watson JD, Crick FHC. Nature. 1953;171:737–738. - PubMed
    1. Chiba S, et al. Nat Immunol. 2012;13:832–842. - PMC - PubMed
    1. Lotze MT, et al. Immunol Rev. 2007;220:60–81. - PubMed
    1. Ndhlovu LC, et al. Blood. 2012;119:3734–3743. - PMC - PubMed
    1. Semino C, Angelini G, Poggi A, Rubartelli A. Blood. 2005;106:609–616. - PubMed