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. 2012 Aug;4(8):331-5.
doi: 10.4103/1947-2714.99501.

Prevalence and association of microalbuminuria in essential hypertensive patients

Bibek Poudel  1 , Binod Kumar Yadav, Ashwini Kumar Nepal, Bharat Jha, Kanak Bahadur Raut
Affiliations

Prevalence and association of microalbuminuria in essential hypertensive patients

Bibek Poudel et al. N Am J Med Sci. 2012 Aug.

Abstract

Background: Microalbuminuria in hypertension has been described as an early sign of kidney damage and a predictor for end stage renal disease and cardiovascular disease. Thus, it is of great importance to study urinary albumin creatinine ratio and progression of kidney disease in hypertensive patients.

Aims: The present study was undertaken to find out the prevalence and association of microalbuminuria in newly diagnosed essential hypertension.

Materials and methods: Newly diagnosed essential hypertensive cases (n = 106) and normotensive controls (n = 106) were enrolled. Hypertension was defined according to Joint national committee-VII definitions. Microalbuminuria was measured using an U-Albumin (NycoCard, Norway) and adjusted for urine creatinine. Descriptive statistics and testing of hypothesis were used for the analysis using SPSS 16 software.

Results: 51.88% of hypertension cases and 13.2% of normotensive controls had microalbuminuria in total population (odds ratio 7.086, P-value <0.001). 46.67% of cases and 12.08% of controls had microalbuminuria in male population (odds ratio 6.375, P-value <0.001). Similarly, 58.7% of cases and 14.58% of controls had microalbuminuria in female population (odds ratio 8.32, P-value <0.001).

Conclusions: By showing strong association between microalbuminuria and hypertension, our findings suggest that microalbuminuria could be a useful marker to assess risk management of cardiovascular disease and renal disease.

Keywords: Albumin creatinine ratio; Hypertension; Microalbuminuria; Normotension.

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Conflict of interest statement

Conflict of Interest: None declared.

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