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. 2013 May;15(5):358-63.
doi: 10.1007/s12094-012-0930-z. Epub 2012 Aug 23.

Polymorphisms in HIF-1alpha affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx

F Mera-Menéndez  1 , A Hinojar-Gutiérrez, M Guijarro Rojas, J García de Gregorio, E Mera-Menéndez, J J Sánchez, M Quintanilla, L Cerezo, C Gamallo
Affiliations

Polymorphisms in HIF-1alpha affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx

F Mera-Menéndez et al. Clin Transl Oncol. 2013 May.

Erratum in

  • Clin Transl Oncol. 2013 May;15(5):416

Abstract

Background: HIF-1alpha plays a key role in the development and progression of cancer. Its polymorphic variants C1772T and G1790A have been associated with greater susceptibility to cancer and increased tumor progression.

Methods: We determined the distribution of these polymorphisms among 121 patients with glottic cancer and 154 healthy volunteers by PCR-RFLP. We also analyzed the relationship between the presence of these polymorphisms and various clinicopathologic variables.

Results: Advanced tumors (T3-T4) were associated with the TT variant (p = 0.036), which was present in 75 % of T4 tumors (p = 0.008). Among patients with nodal metastasis (N+), 41.7 and 22 % were carrying the TT and GA variants, respectively, compared with 9.4 and 2 % of the patients with no metastasis (N0), (p = 0.006 and p = 0.032).

Conclusions: The presence of the TT and GA variants were associated with lymph node metastasis, while the presence of the TT variant can be associated with larger tumor size.

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