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. 2012 Nov;50(11):3738-40.
doi: 10.1128/JCM.01785-12. Epub 2012 Aug 22.

A reliable and reproducible experimental challenge model for peste des petits ruminants virus

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A reliable and reproducible experimental challenge model for peste des petits ruminants virus

Mehdi El Harrak et al. J Clin Microbiol. 2012 Nov.

Abstract

Experimental challenge protocols that consistently reproduce clinical signs of peste des petits ruminants in Alpine goats infected with a tissue culture-passaged peste des petits ruminants virus are described. The protocols can be used to carry out quality-controlled vaccine efficacy and pathogenesis studies under experimental conditions.

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References

    1. Batten CA, et al. 2011. A real time RT-PCR assay for the specific detection of Peste des petits ruminants virus. J. Virol. Methods 171:401–404 - PubMed
    1. Gibbs EP, Taylor WP, Lawman MJ, Bryant J. 1979. Classification of peste des petits ruminants virus as the fourth member of the genus Morbillivirus. Intervirology 11:268–274 - PubMed
    1. Hammouchi M, et al. 17 May 2012. Experimental infection of alpine goats with a Moroccan strain of peste des petits ruminants virus (PPRV).Vet. Microbiol. [Epub ahead of print.] doi/10.1016/j.vetmic.2012.04.043. - PubMed
    1. Rajak KK, et al. 2005. Experimental studies on immunosuppressive effects of peste des petits ruminants (PPR) virus in goats. Comp. Immunol. Microbiol. Infect. Dis. 28:287–296 - PubMed
    1. Saravanan P, et al. 2010. Comparative efficacy of peste des petits ruminants (PPR) vaccines. Biologicals 38:479–485 - PubMed

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