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Meta-Analysis
. 2012 Aug 24:10:170.
doi: 10.1186/1477-7819-10-170.

Systematic review and meta-analysis of Endostar (rh-endostatin) combined with chemotherapy versus chemotherapy alone for treating advanced non-small cell lung cancer

Biaoxue Rong  1 , Shuanying Yang, Wei Li, Wei Zhang, Zongjuan Ming
Affiliations
Meta-Analysis

Systematic review and meta-analysis of Endostar (rh-endostatin) combined with chemotherapy versus chemotherapy alone for treating advanced non-small cell lung cancer

Biaoxue Rong et al. World J Surg Oncol. .

Abstract

Background: Many studies have investigated the efficacy of Endostar combined with platinum-based doublet chemotherapy (PBDC) versus PBDC alone for treating advanced non-small cell lung cancer (NSCLC). This study is a meta-analysis of available evidence.

Methods: Fifteen studies reporting Endostar combined with PBDC versus PBDC alone for treating advanced NSCLC were reviewed. Pooled odds ratios and hazard ratio with 95% confidence intervals were calculated using either the fixed effects model or random effects model.

Results: The overall response rate (ORR) and disease control rate (DCR) of Endostar combined with PBDC for treating NSCLC were significantly higher than those of PBDC alone, with 14.7% and 13.5% improvement, respectively (P < 0.00001). In addition, the time to progression (TTP) and quality of life (QOL) were improved after the treatment of Endostar combined with PBDC (P < 0.00001). The main adverse effects found in this review were hematological reactions, hepatic toxicity, and nausea/vomiting. Endostar combined with PBDC had a similar incidence of adverse reactions compared with PBDC alone (P < 0.05).

Conclusions: Endostar combined with PBDC was associated with higher RR, DCR, and TTP as well as superior QOL profiles compared with PBDC alone. Endostar combined with PBDC had a similar incidence of adverse reactions compared with PBDC alone.

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Figures

Figure 1
Figure 1
Flow chart of literature search. RCTs, randomized controlled trials.
Figure 2
Figure 2
ORR of Endostar combined with PBDC versus PBDC alone for treating NSCLC. GP, gemcitabine + cisplatin; NP, vinorelbine + cisplatin; OR, odds ratio; ORR, overall response rate; PBDC, platinum-based doublet chemotherapy; PP, paclitaxel + cisplatin; RT, radiotherapy; TC, paclitaxel + carboplatin; TP, docetaxel + cisplatin.
Figure 3
Figure 3
DCR of Endostar combined with PBDC versus PBDC alone for treating NSCLC. DCR, disease control rate; GP, gemcitabine + cisplatin; NP, vinorelbine + cisplatin; OR, odds ratio; PBDC, conventional platinum-based doublet chemotherapy; PP, paclitaxel + cisplatin; RT, radiotherapy; TC, paclitaxel + carboplatin; TP, docetaxel + cisplatin.
Figure 4
Figure 4
OYS and QOL improvement of Endostar combined with PBDC versus PBDC alone for treating NSCLC. HR, hazard ratio; OR, odds ratio; OYS, one-year survival rate; PBDC, conventional platinum-based doublet chemotherapy; QOL, quality of life.
Figure 5
Figure 5
TTP of Endostar combined with PBDC versus PBDC alone for treating NSCLC. PBDC, conventional platinum-based doublet chemotherapy; TTP, time to progression.
Figure 6
Figure 6
Meta-analysis of the severe leukopenia and thrombocytopenia between Endostar combined with PBDC and PBDC alone. OR, odds ratios; PBDC, conventional platinum-based doublet chemotherapy.
Figure 7
Figure 7
Meta-analysis of anemia and nausea/vomiting between Endostar combined with PBDC and PBDC alone. OR, odds ratios; PBDC, conventional platinum-based doublet chemotherapy.
Figure 8
Figure 8
Assessment of publication bias. (A) Funnel plot for the ORR of Endostar combined with PBDC versus PBDC alone; (B) Funnel plot for the DCR of Endostar combined with PBDC versus PBDC alone; (C) Begg’s publication bias plot for the ORR of Endostar combined with PBDC versus PBDC alone; (D) Egger’s publication bias plot for the ORR of Endostar combined with PBDC versus PBDC alone.
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References

    1. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001;94:153–156. doi: 10.1002/ijc.1440. - DOI - PubMed
    1. Novello S, Le Chevalier T. Chemotherapy for non-small-cell lung cancer. Part 1: Early-stage disease. Oncology (Williston Park, NY) 2003;17:357–364. - PubMed
    1. Kelly K, Crowley J, Bunn PA, Presant CA, Grevstad PK, Moinpour CM, Ramsey SD, Wozniak AJ, Weiss GR, Moore DF. Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: a Southwest Oncology Group trial. J Clin Oncol. 2001;19:3210–3218. - PubMed
    1. Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J, Johnson DH. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 2002;346:92–98. doi: 10.1056/NEJMoa011954. - DOI - PubMed
    1. Novello S, Pimentel FL, Douillard JY, O’Brien M, von Pawel J, Eckardt J, Liepa AM, Simms L, Visseren-Grul C, Paz-Ares L. Safety and resource utilization by non-small cell lung cancer histology: results from the randomized phase III study of pemetrexed plus cisplatin versus gemcitabine plus cisplatin in chemonaive patients with advanced non-small cell lung cancer. J Thorac Oncol. 2010;5:1602–1608. doi: 10.1097/JTO.0b013e3181eaf30f. - DOI - PubMed

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