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. 2012 Oct 9;48(78):9774-6.
doi: 10.1039/c2cc34665f.

Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence

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Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence

Pasquale Palladino et al. Chem Commun (Camb). .

Abstract

Here we explore the physico-chemical properties of a peptide amphiphile obtained by chemical conjugation of the collagen-stimulating peptide KTTKS with 10,12-pentacosadiynoic acid which photopolymerizes as a stable and extended polydiacetylene. We investigate the self-assembly of this new polymer and rationalize its peculiar behavior in terms of a thermal conformational transition. Surprisingly, this polymer shows a thermal transition associated with a non-cooperative increase in β-sheet content at high temperature.

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