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Editorial
. 2012 Sep 15;11(18):3349-50.
doi: 10.4161/cc.21875. Epub 2012 Aug 23.

TLS/FUS: a protein in cancer and ALS

Adelene Y Tan, James L Manley
Editorial

TLS/FUS: a protein in cancer and ALS

Adelene Y Tan et al. Cell Cycle. .

Abstract

Comment on: Tan AY, et al. Proc Natl Acad Sci USA 2012; 109:6030-5.

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Figures

None
Figure 1. Structures of TLS, EWS, TAF15, CHOP and TLS-CHOP. Domains of TLS, CHOP and TLS-CHOP are depicted, including the activation domain (AD), RGG boxes that contribute to RNA binding (RGG), RNA-binding domain (RBD), Cys2-Cys2 zinc finger (ZF), DNA-binding domain (DBD) and leucine zipper domain (LZ). The location of sarcoma breakpoints (arrowheads) and ALS-related missense mutations in TLS (stars) are also depicted.
See this image and copyright information in PMC

Comment in

  • Tan AY, Riley TR, Coady T, Bussemaker HJ, Manley JL. TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements. Proc Natl Acad Sci U S A. 2012;109:6030–5. doi: 10.1073/pnas.1203028109. doi: 10.1073/pnas.1203028109

References

    1. Tan AY, et al. J Mol Cell Biol. 2009;1:82–92. doi: 10.1093/jmcb/mjp025. - DOI - PMC - PubMed
    1. Strong MJ, et al. FEBS J. 2011;278:3569–77. doi: 10.1111/j.1742-4658.2011.08277.x. - DOI - PubMed
    1. Lagier-Tourenne C, et al. Cell. 2009;136:1001–4. doi: 10.1016/j.cell.2009.03.006. - DOI - PMC - PubMed
    1. Tan AY, et al. Proc Natl Acad Sci USA. 2012;109:6030–5. doi: 10.1073/pnas.1203028109. - DOI - PMC - PubMed
    1. Neumann M, et al. Science. 2006;314:130–3. doi: 10.1126/science.1134108. - DOI - PubMed

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