Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012:2012:546171.
doi: 10.1100/2012/546171. Epub 2012 Jul 31.

Spectroscopic evaluation of glioma grading at 3T: the combined role of short and long TE

E Kousi  1 , I Tsougos, E Tsolaki, K N Fountas, K Theodorou, I Fezoulidis, E Kapsalaki, C Kappas
Affiliations

Spectroscopic evaluation of glioma grading at 3T: the combined role of short and long TE

E Kousi et al. ScientificWorldJournal. 2012.

Abstract

Purpose: To evaluate the diagnostic value of 3T (1)H-MRS in grading cerebral gliomas using short and long echo times.

Methods: 1H-MRS was performed on 71 patients with untreated cerebral gliomas. Metabolite ratios of NAA/Cr, Cho/Cr, Cho/NAA, and mI/Cr were calculated for short and long TE and compared between low and high grade gliomas. Lipids were qualitatively evaluated. ROC analysis was performed to obtain the cut-off values for the metabolic ratios presenting statistical difference between the two glioma grades.

Results: Intratumoral Cho/Cr at both TEs and long TE Cho/NAA were significantly different between low and high grade gliomas. Peritumoral NAA/Cr of both TEs, as well as long TE Cho/Cr and Cho/NAA ratios, significantly differentiated the two tumor grades. Diagnostic sensitivity of peritumoral short TE NAA/Cr proved to be superior over the other metabolic ratios, whereas intratumoral short TE Cho/Cr reached the highest levels of specificity and accuracy. Overall, short TE 1H-MRS reached higher total sensitivity in predicting glioma grade, over long TE.

Conclusion: An advantage was found in using short TE over long TE 1H-MRS in the discrimination of low versus high grade gliomas. Moreover, the results suggested that the peritumoral area of gliomas may be more valuable in predicting glioma grade than using only the intratumoral area.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Intratumoral voxel prescription during SV (a) and 2D-MRSI (b) scan techniques, in a 77-year-old woman with a glioblastoma. For the two scan techniques, the voxel of interest has been placed in similar areas.
Figure 2
Figure 2
In vivo short TE ((a), (b)) and long TE ((c), (d)) mean spectra with their corresponding standard deviations (vertical lines) from the intratumoral area of low grade ((a), (c)) and high grade gliomas ((b), (d)).
Figure 3
Figure 3
Short TE 1H-MR spectra of a 66-years-old male (a) and a 51-year-old female (b) with glioblastoma multiform and anaplastic astrocytoma, respectively. Spectra illustrate high grade glioma intratumoral patterns of (a) dominant LL peak and (b) smaller LL peak with clear evidence of all the other metabolites.
Figure 4
Figure 4
Long TE 1H-MRSI spectra of a 54-year-old male (a) and a 47-year-old female (b) with glioblastoma multiform and anaplastic oligoastrocytoma, respectively. Spectra illustrate high grade glioma intratumoral patterns of (a) high LL peak and (b) absence of LL peak respectively.
Figure 5
Figure 5
In vivo short TE ((a), (b)) and long TE ((c), (d)) mean spectra with their corresponding standard deviations (vertical lines) from the peritumoral area of low grade ((a), (c)) and high grade gliomas ((b), (d)).
Figure 6
Figure 6
Upper graph (a) illustrates the receiver operating characteristic (ROC) curves of intratumoral short TE Cho/Cr and long TE Cho/Cr and Cho/NAA ratios. Lower graphs illustrate ROC curves of peritumoral short TE NAA/Cr, long TE NAA/Cr (b) and long TE Cho/Cr and Cho/NAA (c) ratios, for differentiating low from high grade gliomas.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Martínez-Bisbal MC, Martí-Bonmatí L, Piquer J, et al. 1H and 13C HR-MAS spectroscopy of intact biopsy samples ex vivo and in vivo 1H MRS study of human high grade gliomas. NMR in Biomedicine. 2004;17(4):191–205. - PubMed
    1. Soares DP, Law M. Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications. Clinical Radiology. 2009;64(1):12–21. - PubMed
    1. Jackson RJ, Fuller GN, Abi-Said D, et al. Limitations of stereotactic biopsy in the initial management of gliomas. Neuro-Oncology. 2001;3(3):193–200. - PMC - PubMed
    1. Costanzo A, Scarabino T, Trojsi F, et al. Proton MR spectroscopy of cerebral gliomas at 3 T: spatial heterogeneity, and tumour grade and extent. European Radiology. 2008;18(8):1727–1735. - PubMed
    1. Sjøbakk TE, Lundgren S, Kristoffersen A, et al. Clinical 1 H magnetic resonance spectroscopy of brain metastases at 1.5T and 3T. Acta Radiologica. 2006;47(5):501–508. - PubMed

Publication types