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. 2012:2012:694703.
doi: 10.1100/2012/694703. Epub 2012 Aug 1.

Effects of repetitive hyperbaric oxygen treatment in patients with acute cerebral infarction: a pilot study

Cheng-Hsin Chen  1 , Shao-Yuan Chen, Vinchi Wang, Chao-Ching Chen, Kaw-Chen Wang, Chih-Hao Chen, Yi-Chien Liu, Kuo-Cheng Lu, Ping-Keung Yip, Wen-Ya Ma, Chuan-Chieh Liu
Affiliations

Effects of repetitive hyperbaric oxygen treatment in patients with acute cerebral infarction: a pilot study

Cheng-Hsin Chen et al. ScientificWorldJournal. 2012.

Abstract

The role of hyperbaric oxygen therapy (HBOT) in the treatment of acute ischemic stroke is controversial. This prospective study assessed the efficacy and safety of HBOT as adjuvant treatment on 46 acute ischemic stroke in patients who did not receive thrombolytic therapy. The HBOT group (n = 16) received conventional medical treatment with 10 sessions of adjunctive HBOT within 3-5 days after stroke onset, while the control group (n = 30) received the same treatment but without HBOT. Early (around two weeks after onset) and late (one month after onset) outcomes (National Institutes of Health Stroke Scale, NIHSS scores) and efficacy (changes of NIHSS scores) of HBOT were evaluated. The baseline clinical characteristics were similar in both groups. Both early and late outcomes of the HBOT group showed significant difference (P ≤ 0.001). In the control group, there was only significant difference in early outcome (P = 0.004). For early efficacy, there was no difference when comparing changes of NIHSS scores between the two groups (P = 0.140) but there was statistically significant difference when comparing changes of NIHSS scores at one month (P ≤ 0.001). The HBOT used in this study may be effective for patients with acute ischemic stroke and is a safe and harmless adjunctive treatment.

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Figures

Figure 1
Figure 1
Hyperbaric oxygen therapy in acute ischemic stroke trial.
Figure 2
Figure 2
The clinical outcome (NIHSS score) in the HBOT group. The NIHSS scores were significantly decreased immediately after HBOT and after one month compared to the scores before HBOT (P < 0.001).
Figure 3
Figure 3
The clinical outcome (NIHSS score) in the control group. The NIHSS scores were significantly decreased on the 10th day after stroke (P < 0.05) but without any difference after one month (P = 0.054).
Figure 4
Figure 4
The change of NIHSS scores in both groups. There was no significant NIHSS change on the 10th day after stroke (P = 0.140) but there was significant difference after one month (P = 0.024).
See this image and copyright information in PMC

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