Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012:2012:595734.
doi: 10.5402/2012/595734. Epub 2012 Jul 30.

Thyroid and Hepatic Haemodynamic Alterations among Egyptian Children with Liver Cirrhosis

Zeinab A El-Kabbany  1 , Rasha T Hamza, Ahmed S Abd El Hakim, Lamis M Tawfik
Affiliations

Thyroid and Hepatic Haemodynamic Alterations among Egyptian Children with Liver Cirrhosis

Zeinab A El-Kabbany et al. ISRN Gastroenterol. 2012.

Abstract

Background. Alterations in thyroid hormones regulation and metabolism are frequently observed in patients with cirrhosis. Aims. To assess alterations in thyroid volume (TV), haemodynamics, and hormones in patients with cirrhosis and their relation to hepatic arterial haemodynamics, and disease severity. Methods. Forty cirrhotic patients were compared to 30 healthy subjects regarding TV, free triiodiothyronine (fT(3)), free tetraiodothyronine (fT(4)), thyroid stimulating hormone (TSH), and pulsatility and resistance indices in the inferior thyroid and hepatic arteries. Results. TV (P = 0.042), thyroid volume standard deviation score (TVSDS, P = 0.001), Inferior Thyroid Artery Pulsatility Index (ITAPI, P = 0.001), Inferior Thyroid Artery Resistance Index (ITARI, P = 0.041), Hepatic Artery Pulsatility Index (HAPI, P = 0.029) and Hepatic Artery Resistance Index (HARI, P = 0.035) were higher among cases being highest in Child-C patients. FT(3) was lower in patients than controls (P = 0.001) and correlated negatively with ITAPI (r = -0.71, P = 0.021) and ITARI (r = -0.79, P = 0.011). ITAPI and ITARI correlated directly with HAPI and HARI (r = 0.62, P = 0.03, and r = 0.42, P = 0.04, resp.). Conclusions. Thyroid is involved in the haemodynamic alterations of cirrhosis. Routine study of thyroid by Doppler and assessment of thyroid functions should be performed in patients with cirrhosis to offer proper treatment if needed.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Correlation between hepatic and inferior thyroid arteries pulsatility indices among children with liver cirrhosis.
Figure 2
Figure 2
Correlation between hepatic and inferior thyroid arteries resistance indices among children with liver cirrhosis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Friedman SL. The cellular basis of hepatic fibrosis—mechanisms and treatment strategies. The New England Journal of Medicine. 1993;328(25):1828–1835. - PubMed
    1. Groszmann RJ. Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences. Hepatology. 1994;20(5):1359–1363. - PubMed
    1. Langer DA, Shah VH. Nitric oxide and portal hypertension: interface of vasoreactivity and angiogenesis. Journal of Hepatology. 2006;44(1):209–216. - PubMed
    1. Sabba C, Ferraioli G, Genecin P, et al. Evaluation of postprandial hyperemia in superior mesenteric artery and portal vein in healthy and cirrhotic humans: an operator-blind echo-Doppler study. Hepatology. 1991;13(4):714–718. - PubMed
    1. Fernandez-Sear J, Prieto J, Quiroga J, et al. Systemic and regional hemodynamics in patients with liver cirrhosis and ascites with and without functional renal failure. Gastroenterology. 1989;97(5):1304–1312. - PubMed

LinkOut - more resources