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doi: 10.1016/j.molcel.2012.08.006.
Unwinding to recombine
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- PMID: 22920289
- DOI: 10.1016/j.molcel.2012.08.006
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Comment
Unwinding to recombine
Mol Cell.
.
Free article
Abstract
The MCM proteins are best known for their role in DNA replication, MCM2-7 forming the replicative helicase. Now, two reports in this issue of Molecular Cell, Nishimura et al. (2012) and Lutzmann et al. (2012) show the less well understood MCM8 and MCM9 to be crucial for effective homologous recombination.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.Mol Cell. 2012 Aug 24;47(4):511-22. doi: 10.1016/j.molcel.2012.05.047. Epub 2012 Jul 5. Mol Cell. 2012. PMID: 22771115
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MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.Mol Cell. 2012 Aug 24;47(4):523-34. doi: 10.1016/j.molcel.2012.05.048. Epub 2012 Jul 5. Mol Cell. 2012. PMID: 22771120
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