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Comparative Study
. 2012 Aug 24:11:295.
doi: 10.1186/1475-2875-11-295.

Performance of "VIKIA Malaria Ag Pf/Pan" (IMACCESS®), a new malaria rapid diagnostic test for detection of symptomatic malaria infections

Monidarin Chou  1 , Saorin Kim, Nimol Khim, Sophy Chy, Sarorn Sum, Dany Dourng, Lydie Canier, Chea Nguon, Didier Ménard
Affiliations
Comparative Study

Performance of "VIKIA Malaria Ag Pf/Pan" (IMACCESS®), a new malaria rapid diagnostic test for detection of symptomatic malaria infections

Monidarin Chou et al. Malar J. .

Abstract

Background: Recently, IMACCESS® developed a new malaria test (VIKIA Malaria Ag Pf/Pan™), based on the detection of falciparum malaria (HRP-2) and non-falciparum malaria (aldolase).

Methods: The performance of this new malaria rapid diagnostic test (RDT) was assessed using 1,000 febrile patients seeking malaria treatment in four health centres in Cambodia from August to December 2011. The results of the VIKIA Malaria Ag Pf/Pan were compared with those obtained by microscopy, the CareStart Malaria™ RDT (AccessBio®) which is currently used in Cambodia, and real-time PCR (as "gold standard").

Results: The best performances of the VIKIA Malaria Ag Pf/Pan™ test for detection of both Plasmodium falciparum and non-P. falciparum were with 20-30 min reading times (sensitivity of 93.4% for P. falciparum and 82.8% for non-P. falciparum and specificity of 98.6% for P. falciparum and 98.9% for non-P. falciparum) and were similar to those for the CareStart Malaria™ test.

Conclusions: This new RDT performs similarly well as other commercially available tests (especially the CareStart Malaria™ test, used as comparator), and conforms to the World Health Organization's recommendations for RDT performance. It is a good alternative tool for the diagnosis of malaria in endemic areas.

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Figures

Figure 1
Figure 1
Design of the VIKIA Malaria Ag Pf/Pan™ test.
Figure 2
Figure 2
Map of Cambodia with the locations of the four selected health centres indicated.
Figure 3
Figure 3
Comparative representation of the diagnostic performances of the CareStart Malaria™ test and the VIKIA Malaria Ag Pf/Pan™ test at several reading times (10, 15, 20, 30 and 60 minutes) for detection ofPlasmodium spp. in field study patients, Cambodia, 2011.
Figure 4
Figure 4
Comparative representation of the sensitivities of the CareStart Malaria™ test and the VIKIA Malaria Ag Pf/Pan™ test at several reading times (10, 15, 20, 30 and 60 minutes) for different levels of Plasmodium spp. parasitaemia. Results for Plasmodium falciparum infections, Cambodia, 2011.
Figure 5
Figure 5
Comparative representation of the sensitivities of the CareStart Malaria™ test and the VIKIA Malaria Ag Pf/Pan™ test at several reading times (10, 15, 20, 30 and 60 minutes) for different levels of Plasmodium spp. parasitaemia. Results for non-P. falciparum infections, Cambodia, 2011.
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