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Review
. 2012 Jul 1;6(4):947-53.
doi: 10.1177/193229681200600428.

Insulin delivery device technology 2012: where are we after 90 years?

Andrew Fry  1
Affiliations
Review

Insulin delivery device technology 2012: where are we after 90 years?

Andrew Fry. J Diabetes Sci Technol. .

Abstract

Since the first successful use of insulin in 1921 to treat diabetes at Toronto General Hospital, the major advances in development of the medication itself have taken place in parallel with equally significant developments in the means of delivery. Administration of insulin remains parenteral. This article reviews the main variants in prescription-available delivery technology: vial and syringe, pen injector, needle-free injection, and continuous subcutaneous insulin infusion pumps. For each of these, the background and major milestones are covered briefly and followed by a discussion of the latest product innovations, technologies, and implementations, which are all considered in the context of the interaction with users. The article concludes by reflecting upon how the progress in the technology of diabetes management can best serve the patient. The spectacular technological advances in medication, monitoring, and delivery since 1922 have transformed the lives of millions. However, the fact that we can add sophisticated technology to delivery devices and accessories does not mean it is always the best thing for the patient. Electronic sophistication may be welcomed by a young, eager type 1 diabetes patient, while a senior citizen who discovers he has type 2 diabetes may yearn for simplicity. Technology continues to provide great solutions, but the type of solution delivered must be matched to the user if the maximum benefit is to be achieved for all.

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Figures

Figure 1
Figure 1
Early 1920s insulin syringe kit. Photo courtesy of Eli Lilly and Company archives.
Figure 2
Figure 2
Original NovoPen. Image reproduced with kind permission of NovoNordisk A/S.
Figure 3
Figure 3
Owen Mumford Autopen. Image reproduced with kind permission of Owen Mumford Ltd.
Figure 4
Figure 4
Haselmeier Diapen. Image reproduced with kind permission of Haselmeier GmbH.
Figure 5
Figure 5
Injex 30 NF injector. Image reproduced with kind permission of INJEX Pharma GmbH.
Figure 6
Figure 6
Cellnovo pump and handset. Image reproduced with kind permission of Cellnovo Ltd.
Figure 7
Figure 7
Valeritas V-Go. Image reproduced with kind permission of Valeritas Inc.
Figure 8
Figure 8
Novo InnoLet device. Image reproduced with kind permission of NovoNordisk A/S.
See this image and copyright information in PMC

References

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    1. Hingson RA. The development of the Hypospray for parenteral therapy by jet injection. Anesthesiology. 1949;10(1):66–75. - PubMed
    1. ShareCare.com. How does a jet injector for insulin use work? www.sharecare.com/question/how-jet-injector-insulin-work.