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Comment
. 2012 Nov;14(6):811-2.
doi: 10.1038/aja.2012.88. Epub 2012 Aug 27.

DNA damage, NF-κB and accelerated aging

David G Le Couteur  1 , David J Handelsman
Affiliations
Comment

DNA damage, NF-κB and accelerated aging

David G Le Couteur et al. Asian J Androl. 2012 Nov.

Abstract

The aging process is the major risk factor for disease and disability yet the cellular mechanisms for aging are uncertain. By studying transgenic mice with altered expression of the DNA repair enzyme, ERCC1, it was concluded that DNA damage is an important, if not the primary mechanism for aging. Moreover it was established that altered activity of the transcription factor, NF-κB (nuclear factor kappa B) mediates the effects of DNA damage on aging. Therefore inhibition of NF-κB might have a role in delaying aging.

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Comment on

  • NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
    Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. Tilstra JS, et al. J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18. J Clin Invest. 2012. PMID: 22706308 Free PMC article.

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