Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Sep;61(9):2221-4.
doi: 10.2337/db12-0647.

The artificial pancreas

Jerry Radziuk  1
Affiliations
Comment

The artificial pancreas

Jerry Radziuk. Diabetes. 2012 Sep.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
A simplified model of insulin kinetics/dynamics is shown. Insulin enters either directly into the circulation or is subcutaneously administered. It enters the circulation from where it exerts its action—represented by the effect compartment. A and B: Insulin concentrations (A) and action (B; glucose infusion rates during euglycemic glucose clamp). Subcutaneously administered insulin first enters this compartment from where it is absorbed into the circulation. C and D: Plasma insulin concentrations (C) and action (D) after subcutaneous lispro insulin injection. Schematics in A and B are from our unpublished data; C and D are abstracted from ref. .
See this image and copyright information in PMC

Comment on

References

    1. The Diabetes Control and Complications Trial Research Group The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977–986 - PubMed
    1. Albisser AM, Leibel BS, Ewart TG, et al. Clinical control of diabetes by the artificial pancreas. Diabetes 1974;23:397–404 - PubMed
    1. Pfeiffer EF, Thum CH, Clemens AH. The artificial beta cell—a continuous control of blood sugar by external regulation of insulin infusion (glucose controlled insulin infusion system). Horm Metab Res 1974;6:339–342 - PubMed
    1. Albisser AM, Leibel BS, Ewart TG, Davidovac Z, Botz CK, Zingg W. An artificial endocrine pancreas. Diabetes 1974;23:389–396 - PubMed
    1. Breton M, Farret A, Bruttomesso D, et al. Fully integrated artificial pancreas in type 1 diabetes. Modular closed-loop glucose control maintains near normoglycemia. Diabetes 2012;61:2230–2237 - PMC - PubMed