Loss of pulsatile insulin secretion: a factor in the pathogenesis of type 2 diabetes?
- PMID: 22923651
- PMCID: PMC3425402
- DOI: 10.2337/db12-0664
Loss of pulsatile insulin secretion: a factor in the pathogenesis of type 2 diabetes?
Figures
Comment on
-
Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling.Diabetes. 2012 Sep;61(9):2269-79. doi: 10.2337/db11-1462. Epub 2012 Jun 11. Diabetes. 2012. PMID: 22688333 Free PMC article.
References
-
- Leahy JL, Hirsch IB, Peterson KA, Schneider D. Targeting beta-cell function early in the course of therapy for type 2 diabetes mellitus. J Clin Endocrinol Metab 2010;95:4206–4216 - PubMed
-
- Schofield CJ, Sutherland C. Disordered insulin secretion in the development of insulin resistance and type 2 diabetes. Diabet Med. 24 March 2012 [Epub ahead of print] - PubMed
-
- Pørksen N, Munn S, Steers J, Vore S, Veldhuis J, Butler P. Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting. Am J Physiol 1995;269:E478–E488 - PubMed
-
- Hellman B, Salehi A, Gylfe E, Dansk H, Grapengiesser E. Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets. Endocrinology 2009;150:5334–5340 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
