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. 2012 Sep 7;14(17):4594-7.
doi: 10.1021/ol3020557. Epub 2012 Aug 27.

Direct carbo-acylation reactions of 2-arylpyridines with α-diketones via Pd-catalyzed C-H activation and selective C(sp2)-C(sp2) cleavage

Wei Zhou  1 , Hongji Li, Lei Wang
Affiliations

Direct carbo-acylation reactions of 2-arylpyridines with α-diketones via Pd-catalyzed C-H activation and selective C(sp2)-C(sp2) cleavage

Wei Zhou et al. Org Lett. .

Abstract

An efficient carbo-acylation reaction of 2-arylpyridines with α-diketones via Pd-catalyzed C-H bond activation and C-C bond cleavage in the presence of TBHP was developed that generated aryl ketones in good yields. The highly selective formation of aryl ketones was observed when 2-arylpyridines reacted with aromatic/aliphatic α-diketones.

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