Comment on

• Mast cells are essential intermediaries in regulatory T-cell tolerance.

  Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, Scott ZA, Coyle AJ, Reed JL, Van Snick J, Strom TB, Zheng XX, Noelle RJ. Lu LF, et al. Nature. 2006 Aug 31;442(7106):997-1002. doi: 10.1038/nature05010. Epub 2006 Aug 20. Nature. 2006. PMID: 16921386
• CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction.

  Gri G, Piconese S, Frossi B, Manfroi V, Merluzzi S, Tripodo C, Viola A, Odom S, Rivera J, Colombo MP, Pucillo CE. Gri G, et al. Immunity. 2008 Nov 14;29(5):771-81. doi: 10.1016/j.immuni.2008.08.018. Immunity. 2008. PMID: 18993084 Free PMC article.
• Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation.

  Piconese S, Gri G, Tripodo C, Musio S, Gorzanelli A, Frossi B, Pedotti R, Pucillo CE, Colombo MP. Piconese S, et al. Blood. 2009 Sep 24;114(13):2639-48. doi: 10.1182/blood-2009-05-220004. Epub 2009 Jul 30. Blood. 2009. PMID: 19643985
• Mast cell degranulation breaks peripheral tolerance.

  de Vries VC, Wasiuk A, Bennett KA, Benson MJ, Elgueta R, Waldschmidt TJ, Noelle RJ. de Vries VC, et al. Am J Transplant. 2009 Oct;9(10):2270-80. doi: 10.1111/j.1600-6143.2009.02755.x. Epub 2009 Jul 22. Am J Transplant. 2009. PMID: 19681828 Free PMC article.
• Mast cells condition dendritic cells to mediate allograft tolerance.

  de Vries VC, Pino-Lagos K, Nowak EC, Bennett KA, Oliva C, Noelle RJ. de Vries VC, et al. Immunity. 2011 Oct 28;35(4):550-61. doi: 10.1016/j.immuni.2011.09.012. Immunity. 2011. PMID: 22035846 Free PMC article.
• Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.

  Feyerabend TB, Weiser A, Tietz A, Stassen M, Harris N, Kopf M, Radermacher P, Möller P, Benoist C, Mathis D, Fehling HJ, Rodewald HR. Feyerabend TB, et al. Immunity. 2011 Nov 23;35(5):832-44. doi: 10.1016/j.immuni.2011.09.015. Immunity. 2011. PMID: 22101159