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Review
. 2013 Mar;85(3):373-82.
doi: 10.1016/j.critrevonc.2012.08.002. Epub 2012 Aug 25.

Pneumocystis jirovecii pneumonia prophylaxis during temozolomide treatment for high-grade gliomas

Filip Y De Vos  1 , Johanna M Gijtenbeek, Chantal P Bleeker-Rovers, Carla M van Herpen
Affiliations
Review

Pneumocystis jirovecii pneumonia prophylaxis during temozolomide treatment for high-grade gliomas

Filip Y De Vos et al. Crit Rev Oncol Hematol. 2013 Mar.

Abstract

High-grade glioma patients receiving concomitant chemoradiotherapy with temozolomide 75mg/m(2) during six to seven weeks or dose-dense temozolomide regimens especially in combination with chronic use of corticosteroids have a high risk for developing Pneumocystis jirovecii pneumonia. In this review, we define risk groups and propose a guideline for prophylaxis using risk stratification.

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