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. 1979 Sep;31(3):841-4.
doi: 10.1128/JVI.31.3.841-844.1979.

Regulation of persistent infection with herpes simplex virus in vitro by hydrocortisone

Y Nishiyama, F Rapp

Regulation of persistent infection with herpes simplex virus in vitro by hydrocortisone

Y Nishiyama et al. J Virol. 1979 Sep.

Abstract

About 1% of Raji cells showed sensitivity to herpes simplex virus type 2 (HSV-2) infection when tested by infectious center assays or immunofluorescence tests, and the percentage did not change during cell passage. The addition of hydrocortisone to Raji cells persistently infected with HSV-2 caused a marked increase in virus production and in the number of HSV-producing cells. In the case of HSV-1, it was shown that the addition of hydrocortisone was required to maintain persistent infection. These observations suggest that control of replication of HSV-1 and HSV-2 in these cells is regulated by different mechanisms.

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