Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jul;18(7):740-2.
doi: 10.1038/mp.2012.120. Epub 2012 Aug 28.

Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia

S Kano, C Colantuoni, F Han, Z Zhou, Q Yuan, A Wilson, Y Takayanagi, Y Lee, J Rapoport, W Eaton, N Cascella, H Ji, D Goldman, A Sawa

Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia

S Kano et al. Mol Psychiatry. 2013 Jul.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Effects of SZ-associated epigenetic alterations on gene expression. (a) Genes whose expression levels are significantly affected by altered H3K4me3 and/or H3K27me3 levels associated with SZ. See Supplementary Table 2 for the full analysis results. Data from subject 1 were not included in the reference distribution for the H3K4me3 data because it led to artifacts in the resulting distributions. None of the 22 genes survived multiple-testing corrections. (b) qRT-PCR validation of microarray data for MGST1, DAAM2 and LPXN mRNA. qRT-PCR data were normalized by β-actin mRNA expression. (c) Venn diagram of functional groups significantly altered in SZ in pathway analysis: 72 pathways showed significant changes both in ChIP-seq and microarray studies. False discovery rate, q<0.01. See Supplementary Tables 3 and 4 for full analysis data. (d) Representative pathways that are potentially related to schizophrenia among the 72 pathways from c. See Supplementary Table 5 for full analysis data. FC, fold change.
See this image and copyright information in PMC

References

    1. Feinberg AP. Nature. 2007;447:433–440. - PubMed
    1. Gluckman PD, Hanson MA, Buklijas T, Low FM, Beedle AS. Nat Rev Endocrinol. 2009;5:401–408. - PubMed
    1. Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, et al. Nature. 2007;448:553–560. - PMC - PubMed
    1. Cheung I, Shulha HP, Jiang Y, Matevossian A, Wang J, Weng Z, et al. Proc Natl Acad Sci USA. 2010;107:8824–8829. - PMC - PubMed
    1. Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, et al. J Neurosci. 2007;27:11254–11262. - PMC - PubMed