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Clinical Trial
. 1990 Dec;53(12):1096-8.
doi: 10.1136/jnnp.53.12.1096.

Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine

T Bottiglieri  1 , P Godfrey, T Flynn, M W Carney, B K Toone, E H Reynolds
Affiliations
Clinical Trial

Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine

T Bottiglieri et al. J Neurol Neurosurg Psychiatry. 1990 Dec.

Abstract

Cerebrospinal fluid (CSF) S-adenosylmethionine (SAM) levels were significantly lower in severely depressed patients than in a neurological control group. The administration of SAM either intravenously or orally is associated with a significant rise of CSF SAM, indicating that it crosses the blood-brain barrier in humans. These observations provide a rational basis for the antidepressant effect of SAM, which has been confirmed in several countries. CSF SAM levels were low in a group of patients with Alzheimer's dementia suggesting a possible disturbance of methylation in such patients and the need for trials of SAM treatment.

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References

    1. Sci Am. 1989 Jan;260(1):40-7 - PubMed
    1. Ala J Med Sci. 1988 Jul;25(3):306-13 - PubMed
    1. Lancet. 1967 May 20;1(7499):1086-8 - PubMed
    1. Br Med J. 1967 Dec 2;4(5578):512-6 - PubMed
    1. Adv Biochem Psychopharmacol. 1982;32:175-80 - PubMed

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