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Review
. 2012:2012:413767.
doi: 10.1155/2012/413767. Epub 2012 Aug 13.

Challenging regional psoriasis and ustekinumab biotherapy: impact of the patterns of disease

Trinh Hermanns-Lê  1 , Enzo Berardesca, Gérald E Piérard, Marianne Lesuisse, Claudine Piérard-Franchimont
Affiliations
Review

Challenging regional psoriasis and ustekinumab biotherapy: impact of the patterns of disease

Trinh Hermanns-Lê et al. J Biomed Biotechnol. 2012.

Abstract

In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations.

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References

    1. Piérard GE, Piérard-Franchimont C, Szepetiuk G, Paquet P, Quatresooz P. The therapeutic potential of TNF-α antagonists for skin psoriasis comorbidities. Expert Opinion on Biological Therapy. 2010;10(8):1197–1208. - PubMed
    1. Kragballe K. Management of difficult to treat locations of psoriasis: scalp, face, flexures, palm/soles and nails. Current Problems in Dermatology. 2009;38:160–171. - PubMed
    1. McGonagle D, Palmou Fontana N, Tan AL, Benjamin M. Nailing down the genetic and immunological basis for psoriatic disease. Dermatology. 2010;221(supplement 1):S15–S22. - PubMed
    1. Griffiths CEM. Comparing biological therapies in psoriasis: implications for clinical practice. Journal of the European Academy of Dermatology and Venereology. 2010;24(supplement 6):S10–S14. - PubMed
    1. Prinz JC. From bench to bedside—translational research in psoriasis. Journal of the European Academy of Dermatology and Venereology. 2010;24(supplement 6):S1–S4. - PubMed