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. 2012:2012:839242.
doi: 10.5402/2012/839242. Epub 2012 Aug 8.

The Platelet Function Analyzer (PFA-100) as a Screening Tool in Neurosurgery

Ralf Karger  1 , Karoline Reuter, Jochen Rohlfs, Christopher Nimsky, Ulrich Sure, Volker Kretschmer
Affiliations

The Platelet Function Analyzer (PFA-100) as a Screening Tool in Neurosurgery

Ralf Karger et al. ISRN Hematol. 2012.

Abstract

We investigated whether the inclusion of the PFA-100 in the preoperative screening of neurosurgical patients might reduce perioperative bleeding complications. Patients with intracranial space-occupying lesions who were scheduled for neurosurgery underwent routine preoperative PFA-100 testing. In case of an abnormal PFA test, patients received prophylactic treatment with desmopressin. 93 consecutive patients were compared to 102 consecutive patients with comparable characteristics operated before introduction of the PFA-100 testing. 2 patients (2.2%) in the PFA group and 2 patients (2.0%) in the non-PFA group experienced clinically relevant intracranial bleeding confirmed by computed tomography (OR 1.05, 95% CI 0.39-2.82; P = 1.0). Transfusions were not significantly different between the two groups. 13 (14.0%) patients in the PFA group and 5 (4.9%) patients in the non-PFA group received desmopressin (OR 3.2, 95% CI 1.1-9.2; P = 0.045). Preoperative screening with the PFA-100 did result in a significant increase in the administration of desmopressin, which could not reduce perioperative bleeding complications or transfusions.

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References

    1. Palmer JD, Sparrow OC, Iannotti F, Horwitz NH, Hoff JT. Postoperative hematoma: a 5-year survey and identification of avoidable risk factors. Neurosurgery. 1994;35(6):1061–1065. - PubMed
    1. Taylor WAS, Thomas NWM, Wellings JA, Bell BA. Timing of postoperative intracranial hematoma development and implications for the best use of neurosurgical intensive care. Journal of Neurosurgery. 1995;82(1):48–50. - PubMed
    1. Chernov MF, Ivanov PI. Urgent reoperation for major regional complications after removal of intracranial tumors: outcome and prognostic factors in 100 consecutive cases. Neurologia Medico-Chirurgica. 2007;47(6):243–248. - PubMed
    1. Serious Hazards of Transfusion (SHOT) 2011, http://www.shotuk.org/.
    1. Seifried E, Klueter H, Weidmann C, et al. How much blood is needed? Vox Sanguinis. 2011;100(1):10–21. - PubMed

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