Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012;2(1):29-41.
Epub 2012 Mar 15.

Nanomaterials and nanotechnology for skin tissue engineering

Aezeden Mohamed  1 , Malcolm Mengqiu Xing
Affiliations

Nanomaterials and nanotechnology for skin tissue engineering

Aezeden Mohamed et al. Int J Burns Trauma. 2012.

Abstract

A recent literature review of the field shows that tissue-engineered skin has been in clinical use for the last several decades and that, over this time the technology has advanced rapidly. Despite this progress no synthetic skin yet produced has completely replicated normal, healthy skin. Therefore, researchers must continue to develop materials that successfully overcome the problems with current skin tissue substitutes. This paper is a comprehensive review of the prospects for nanotechnology and nanomaterials to close this gap by mimicking surface properties for reconstruction of a variety of skin tissues. In addition, a number of commercially available products that regenerate different layers of the burn-damaged or chronically wounded skin are reviewed.

Keywords: Skin; regeneration; scaffold; tissue engineering.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic presentation of tissue engineering methodology (A) cell culture (B) biogradable nanofiber scaffold (C) cell seeded on scaffold (D) tissue grown on bioreactor.
Figure 2
Figure 2
Schematic of skin structure [69].
See this image and copyright information in PMC

References

    1. Liu WaYC. Application of scaffold materials in tissue reconstruction in immunecompetent mammals: Our experience and future requirements. Biomaterials. 2007;28:5078–5086. - PubMed
    1. Sachlos E, Czernuszka JT. Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cell Mater. 2003;5:29–39. discussion 39-40. - PubMed
    1. Huang Z-M, Zhang YZ, Ramakrishna S, Lim CT. Electrospinning and mechanical characterization of gelatin nanofibers. Polymer. 2004;45:5361–5368.
    1. Matthews JA, Boland ED, Wnek GE, Simpson DG, Bowlin GL. Electrospinning of collagen type II: A feasibility study. Journal of Bioactive and Compatible Polymers. 2003;18:125–134.
    1. Zambuzzi WF, et al. Biological behavior of pre-osteoblasts on natural hydroxyapatite: A study of signaling molecules from attachment to differentiation. Journal of Biomedical Materials Research Part A. 2011;97:193–200. - PubMed

LinkOut - more resources