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Review
. 2012 Oct;26(10):1651-9.
doi: 10.1210/me.2012-1150. Epub 2012 Aug 28.

Minireview: applications of next-generation sequencing on studies of nuclear receptor regulation and function

Clifford A Meyer  1 , Qianzi Tang, X Shirley Liu
Affiliations
Review

Minireview: applications of next-generation sequencing on studies of nuclear receptor regulation and function

Clifford A Meyer et al. Mol Endocrinol. 2012 Oct.

Abstract

Next-generation sequencing technologies have expanded the experimental possibilities for studying the genome-wide regulation of transcription by nuclear receptors, their collaborating transcription factors, and coregulators. These technologies allow investigators to obtain abundance and DNA sequence information in a single experiment. In this review, we highlight proven and potential uses of next-generation sequencing in the study of gene regulation by nuclear receptors. We also provide suggestions on how to effectively leverage this technology in a collaborative environment.

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Figures

Fig. 1.
Fig. 1.
Next-generation sequencing applications in studies of transcriptional regulation. Applications in red make use mainly of the quantification of abundance, whereas applications in blue make use of sequence-based observations.
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