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Case Reports
. 2012 Aug;12(4):333-7.
doi: 10.7861/clinmedicine.12-4-333.

Hyperparathyroidism in chronic kidney disease: complexities within the commonplace

Michael M Cai  1 , Lawrence P McMahon, Edward R Smith, David S Williams, Stephen G Holt
Affiliations
Case Reports

Hyperparathyroidism in chronic kidney disease: complexities within the commonplace

Michael M Cai et al. Clin Med (Lond). 2012 Aug.

Abstract

Secondary hyperparathyroidism in patients with chronic kidney disease (CKD) is common and usually caused by associated metabolic abnormalities, in particular, hypocalcaemia and hyperphosphataemia. Nevertheless, other causes of hyperparathyroidism can exist concurrently with CKD, challenging diagnostic interpretation and therapeutic intervention. We present four cases of hyperparathyroidism in patients with CKD that highlight some of these dilemmas.

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Figures

Fig 1.
Fig 1.
99Tc-Sestamibi scan showing an intense focus of uptake in the region of the left lower pole of the thyroid (Case 1).
Fig 2.
Fig 2.
(a) ultrasound showing a very large parathyroid mass. (b) at parathyroidectomy, the mass was easily localized and removed.
Fig 3.
Fig 3.
Renal transplant biopsy showing nephrocalcinosis with interstitial calcium deposit (arrow) and inflammatory changes.
See this image and copyright information in PMC

References

    1. Levin A, Bakris GL, Molitch M, et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int 2006;71:31–8. 10.1038/sj.ki.5002009 - DOI - PubMed
    1. Rampoldi L, Sclori F, Amoroso A, et al. The rediscovery of uromodulin (Tamm-Horsfall protein): from tubulointerstitial nephropathy to chronic kidney disease. Kidney Int 2011;80:338–47. 10.1038/ki.2011.134 - DOI - PubMed
    1. Carone FA, Epstein FH, Beck D, Levitin H. The effects upon the kidney of transient hypercalcemia induced by parathyroid extract. Am J Pathol 1960;36:77–103. - PMC - PubMed
    1. Procino G, Carmosino M, Tamma G, et al. Extracellular calcium antagonizes forskolin-induced aquaporin 2 trafficking in collecting duct cells. Kidney Int 2004;66:2245–55. 10.1111/j.1523-1755.2004.66036.x - DOI - PubMed
    1. Levi M, Ellis MA, Berl T. Control of renal hemodynamics and glomerular filtration rate in chronic hypercalcemia. J Clin Invest 1983;71:1624–32. 10.1172/JCI110918 - DOI - PMC - PubMed

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