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Randomized Controlled Trial
. 2013 Feb;260(2):458-61.
doi: 10.1007/s00415-012-6655-7. Epub 2012 Aug 30.

A randomized clinical trial of lithium in multiple system atrophy

Francesco Saccà  1 , Angela Marsili, Mario Quarantelli, Vincenzo Brescia Morra, Arturo Brunetti, Rosa Carbone, Chiara Pane, Giorgia Puorro, Cinzia Valeria Russo, Elena Salvatore, Tecla Tucci, Giuseppe De Michele, Alessandro Filla
Affiliations
Randomized Controlled Trial

A randomized clinical trial of lithium in multiple system atrophy

Francesco Saccà et al. J Neurol. 2013 Feb.

Abstract

The aim of our study was to test the safety and tolerability of lithium in multiple system atrophy (MSA). The study was randomized, placebo-controlled, and double-blind. The primary endpoint of the study was safety and tolerability. An interim analysis, performed 1 year after the first patient was randomized, showed a higher proportion of trial abandon (P < 0.01) and a higher number of adverse events (P < 0.02) in the lithium group. The trial was stopped by the Data Monitoring Committee. Overall, lithium was not well tolerated, and we do not encourage future studies with lithium in MSA patients.

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References

    1. Neurology. 2011 Sep 6;77(10):973-9 - PubMed
    1. Neurology. 2008 Aug 26;71(9):670-6 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1989 Jun;Suppl:78-89 - PubMed
    1. J Cell Biol. 2005 Sep 26;170(7):1101-11 - PubMed
    1. Mov Disord. 2004 Dec;19(12):1391-402 - PubMed

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