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Case Reports
. 2012:2012:215038.
doi: 10.1155/2012/215038. Epub 2012 May 17.

Cushing's Syndrome due to Ectopic ACTH from Bronchial Carcinoid: A Case Report and Review

Manohara Kenchaiah  1 , Steve Hyer
Affiliations
Case Reports

Cushing's Syndrome due to Ectopic ACTH from Bronchial Carcinoid: A Case Report and Review

Manohara Kenchaiah et al. Case Rep Endocrinol. 2012.

Abstract

Despite advances in analytic and imaging techniques, the syndrome of ectopic adrenocorticotrophic hormone (ACTH) secretion from a tumour resulting in Cushing's syndrome continues to pose difficult diagnostic and therapeutic challenges. Dynamic testing may be equivocal and radiology indeterminate. We report a patient presenting with Cushing's syndrome associated with ectopic ACTH secretion from a bronchial carcinoid whose management presented diagnostic and therapeutic challenges.

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Figures

Figure 1
Figure 1
PA chest X-ray showing ill-defined opacity right lower zone (arrow).
Figure 2
Figure 2
CT chest showing right lower lobe pulmonary nodule (arrow).
Figure 3
Figure 3
Histology of pulmonary specimen. H&E staining. Original magnification ×200. Histology demonstrates typical cuboidal cells with granules. Specific immunostaining (not shown) was strongly positive for ACTH, CD56, chromogranin and synaptophysin.
See this image and copyright information in PMC

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