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. 2012 Aug 1;1(5):751-753.
doi: 10.4161/onci.19570.

Tumor conditioned media from colorectal cancer patients inhibits dendritic cell maturation

Adriana J Michielsen  1 , Jacintha N O'Sullivan, Elizabeth J Ryan
Affiliations

Tumor conditioned media from colorectal cancer patients inhibits dendritic cell maturation

Adriana J Michielsen et al. Oncoimmunology. .

Abstract

Tumors inhibit dendritic cell maturation and function in order to evade host immunity. We showed that conditioned media from tumor explant tissue, taken from metastatic colorectal cancer patients, significantly inhibits maturation of dendritic cells.

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Figures

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Figure 1. The tumor microenvironment inhibits dendritic cell maturation and function in response to LPS. Tumors produce a large array of soluble factors, which inhibit LPS induced dendritic cell (DC) maturation (A). In addition, they affect DC function by increasing IL-10 and decreasing IL-12p70 secretion (B). VEGF, CCL2, CXCL1 and CXCL5, which are secreted at high levels by the tumor, affect DC function by inhibiting LPS induced IL-12p70 secretion (C).
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