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. 2012 Sep 27;55(18):8183-7.
doi: 10.1021/jm3007454. Epub 2012 Sep 7.

Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity

Sheng-Ping Yang  1 , Xiao-Wei Zhang, Jing Ai, Li-She Gan, Jin-Biao Xu, Ying Wang, Zu-Shang Su, Lu Wang, Jian Ding, Mei-Yu Geng, Jian-Min Yue
Affiliations

Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity

Sheng-Ping Yang et al. J Med Chem. .

Abstract

Eucalyptin A (1), together with two known compounds 2 and 3 exhibiting potent inhibition on HGF/c-Met axis, was discovered from the fruits of Eucalyptus globulus. 1 possessed an unprecedented carbon framework of phloroglucinol-coupled sesquiterpenoid, and its structure was elucidated by spectroscopic method and ECD calculation. A brief structure-activity relationship discussion indicated that the coupling of a phloroglucinol and a sesquiterpenoid is essential for the activity.

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