Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Nov;43(11):2858-64.
doi: 10.1161/STROKEAHA.112.660332. Epub 2012 Aug 30.

Short sleep duration is associated with carotid intima-media thickness among men in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Megan R Sands  1 , Diane S Lauderdale, Kiang Liu, Kristen L Knutson, Karen A Matthews, Charles B Eaton, Crystal D Linkletter, Eric B Loucks
Affiliations

Short sleep duration is associated with carotid intima-media thickness among men in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Megan R Sands et al. Stroke. 2012 Nov.

Abstract

Background and purpose: Carotid intima-media thickness (CIMT) is a subclinical marker of cardiovascular disease. Recent studies suggest that shorter sleep duration is a risk factor for cardiovascular disease, but there is limited evidence regarding this association using high-quality, objective assessments of sleep. The aim of this study is to determine whether sleep duration is associated with CIMT.

Methods: The study used an observational cohort consisting of 617 black and white middle-aged healthy participants (37-52 years; 58% female) in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Multivariable-adjusted linear regression analyses were performed. Sleep duration was measured using wrist actigraphy monitors. CIMT was calculated using the average of 20 measurements of the mean common carotid, bulb, and internal CIMT, which was assessed using ultrasound images.

Results: After adjusting for covariates, 1 hour of longer sleep duration was associated with 0.026 mm less CIMT among men (P=0.02; 95% CI, -0.047 to -0.005) and 0.001 mm less CIMT among women (P=0.91; 95% CI, -0.020 to 0.022). Segment-specific analyses indicated that the carotid bulb was a key driver of the observed association.

Conclusions: Shorter objectively assessed sleep duration was associated with greater CIMT among men but not women.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Objectively assessed sleep duration and carotid CIMT adjusted for age and race - presented by sex (includes 95% confidence intervals)
Figure 1
Figure 1
Objectively assessed sleep duration and carotid CIMT adjusted for age and race - presented by sex (includes 95% confidence intervals)
See this image and copyright information in PMC

References

    1. Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA. Sleep duration predicts cardiovascular outcomes: A systematic review and meta-analysis of prospective studies. Eur Heart J - PubMed
    1. Gallicchio L, Kalesan B. Sleep duration and mortality: A systematic review and meta-analysis. J Sleep Res. 2009;18:148–158. - PubMed
    1. Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S, et al. Meta-analysis of short sleep duration and obesity in children and adults. Sleep. 2008;31:619–626. - PMC - PubMed
    1. Wolff B, Volzke H, Schwahn C, Robinson D, Kessler C, John U. Relation of self-reported sleep duration with carotid intima-media thickness in a general population sample. Atherosclerosis. 2008;196:727–732. - PubMed
    1. Silva GE, Goodwin JL, Sherrill DL, Arnold JL, Bootzin RR, Smith T, et al. Relationship between reported and measured sleep times: The sleep heart health study (shhs) Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 2007;3:622–630. - PMC - PubMed

Publication types