Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Sep 11;109(37):14724-5.
doi: 10.1073/pnas.1212243109. Epub 2012 Aug 30.

Measles immunometrics

Theodore C Pierson  1 , Jonathan W Yewdell
Affiliations
Comment

Measles immunometrics

Theodore C Pierson et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The dynamics of MV clearance. MV infection results in transient viremia (purple line, Lower) that is cleared within ∼2 wk, coincident with CD8+ T-cell responses. MV RNA (red line, Lower) persists, however, for as long as months in blood. In the acute phase of infection, most MV is likely produced by infected lymphocytes. The source of persistent MV RNA is unknown, but could come from infected lymphocytes, follicular dendritic cells, or possibly other cell types, including epithelial cells in lung, liver, or kidney. Lin et al.’s modeling studies (9) point to an important role for Abs in clearing persistently infected cells that are the source of MV RNA.
See this image and copyright information in PMC

Comment on

References

    1. WHO Global reductions in measles mortality 2000-2008 and the risk of measles resurgence. Wkly Epidemiol Rec. 2009;84:509–516. - PubMed
    1. Moss WJ, Griffin DE. Measles. Lancet. 2012;379:153–164. - PubMed
    1. Chen RT, et al. Measles antibody: Reevaluation of protective titers. J Infect Dis. 1990;162:1036–1042. - PubMed
    1. Griffin DE, Lin WH, Pan CH. Measles virus, immune control, and persistence. FEMS Microbiol Rev. 2012;36:649–662. - PMC - PubMed
    1. Permar SR, et al. Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys. J Infect Dis. 2004;190:998–1005. - PubMed