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Editorial
. 2012 Sep;92(3):409-11.
doi: 10.1189/jlb.0612269.

Editorial: TRPV1: how thymocytes sense stress and respond with autophagy

Ian X McLeod, You-Wen He
Editorial

Editorial: TRPV1: how thymocytes sense stress and respond with autophagy

Ian X McLeod et al. J Leukoc Biol. 2012 Sep.

Abstract

Discussion on discovery of the roles of TRPV1 in thymocyte autophagy, and its relevance.

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Figures

Figure 1.
Figure 1.. Capsaicin induces prosurvival autophagy in CD4+CD8+ double-positive thymocytes through TRPV1 activation, which is inhibited by chlorpromazine (CPZ).
TRPV1 activation, in turn, results in calcium influx, inhibited by chelation using EDTA, and ROS production, which can be scavenged by N-acetylcysteine (NAC). This leads to AMPK activation, which is inhibited by compound C. Additionally, Beclin-1 and Atg4c are transcriptionally up-regulated, and Atg4c is oxidized. The net result is an activation of microtubule-associated protein 1 LC3 processing and activation of autophagy, which protects the CD4 CD8 DPdull thymocytes from apoptosis.
See this image and copyright information in PMC

Comment on

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