Comment
doi: 10.1016/j.cell.2012.08.008.
Singles engage the RNA interference pathway
- PMID: 22939614
- DOI: 10.1016/j.cell.2012.08.008
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Comment
Singles engage the RNA interference pathway
Cell.
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Free article
Abstract
Single-stranded RNAs interact with components of the RNA interference pathway to reduce the expression of target mRNAs. Now, Lima et al. and Yu et al. show that, with extensive chemical modifications, small single-stranded RNAs can robustly induce gene silencing with efficacy similar to their double-stranded counterparts.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Single-stranded siRNAs activate RNAi in animals.Cell. 2012 Aug 31;150(5):883-94. doi: 10.1016/j.cell.2012.08.014. Cell. 2012. PMID: 22939618
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Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.Cell. 2012 Aug 31;150(5):895-908. doi: 10.1016/j.cell.2012.08.002. Cell. 2012. PMID: 22939619 Free PMC article.
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