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doi: 10.1016/j.cell.2012.08.006.
Holding on through DNA replication: histone modification or modifier?
- PMID: 22939615
- DOI: 10.1016/j.cell.2012.08.006
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Holding on through DNA replication: histone modification or modifier?
Cell.
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Abstract
Histone methylation is widely believed to contribute to epigenetic inheritance by persevering through DNA replication and subsequently templating methylation of daughter chromosome regions. However, a report in this issue (Petruk et al.) suggests that chromatin association of the methytransferase complexes themselves persists through replication and re-establishes histone methylation.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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TrxG and PcG proteins but not methylated histones remain associated with DNA through replication.Cell. 2012 Aug 31;150(5):922-33. doi: 10.1016/j.cell.2012.06.046. Epub 2012 Aug 23. Cell. 2012. PMID: 22921915 Free PMC article.
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