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Review
. 2013 Jun;54(2):258-63.
doi: 10.1016/j.bone.2012.08.121. Epub 2012 Aug 23.

Osteocyte control of osteoclastogenesis

Charles A O'Brien  1 , Tomoki Nakashima, Hiroshi Takayanagi
Affiliations
Review

Osteocyte control of osteoclastogenesis

Charles A O'Brien et al. Bone. 2013 Jun.

Abstract

Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine RANKL involved in osteoclast formation in cancellous bone. The goal of this review is to discuss these and other studies that reveal mechanisms whereby osteocytes control osteoclast formation and thus bone resorption.

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Figures

Fig. 1
Fig. 1
Signals controlling RANKL production by osteocytes.
See this image and copyright information in PMC

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