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Review
. 2012 Oct;33(10):1217-45.
doi: 10.1038/aps.2012.90. Epub 2012 Sep 3.

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

Cheng-Shi Jiang  1 , Lin-fu Liang, Yue-wei Guo
Affiliations
Review

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

Cheng-Shi Jiang et al. Acta Pharmacol Sin. 2012 Oct.

Abstract

This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.

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Figures

Figure 1
Figure 1
Structures of flavonoids 1–27.
Figure 2
Figure 2
Structures of flavonoids 28–42.
Figure 3
Figure 3
Structures of flavonoids 43–79.
Figure 4
Figure 4
Structures of flavonoids 80–104.
Figure 5
Figure 5
Structures of flavonoids 105–118.
Figure 6
Figure 6
Structures of bromophenols 119–135.
Figure 7
Figure 7
Structures of phenolic acids 136–153.
Figure 8
Figure 8
Structures of phenolics containing furan or pyran ring 154–165.
Figure 9
Figure 9
Structures of phenolics containing furan or pyran ring 166–183.
Figure 10
Figure 10
Structures of coumarins and lignans 184–189.
Figure 11
Figure 11
Structures of coumarins and lignans 190–200.
Figure 12
Figure 12
Structures of sesquiterpenes 201–213.
Figure 13
Figure 13
Structures of diterpenes 214–232.
Figure 14
Figure 14
Structures of sesterterpenes 233–236.
Figure 15
Figure 15
Structures of triterpenes 237–270.
Figure 16
Figure 16
Structures of steroids 271–276.
Figure 17
Figure 17
Structures of N- or S-containing compounds 277–292.
Figure 18
Figure 18
Structures of miscellaneous 293–305.
See this image and copyright information in PMC

References

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