Visualizing global effects of the DNA damage response
- PMID: 22945255
- DOI: 10.1038/ncb2571
Visualizing global effects of the DNA damage response
Abstract
In a large-scale analysis, the effects of DNA damage on the levels and localization of almost every protein in an organism have now been tracked in living cells. It is shown that that although many proteins change their position or concentration, they rarely do both.
Comment on
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Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.Nat Cell Biol. 2012 Sep;14(9):966-76. doi: 10.1038/ncb2549. Epub 2012 Jul 29. Nat Cell Biol. 2012. PMID: 22842922 Free PMC article.
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