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. 1990 Jan 5;247(4938):72-4.
doi: 10.1126/science.2294593.

Mechanism of insect resistance to the microbial insecticide Bacillus thuringiensis

J Van Rie  1 , W H McGaughey, D E Johnson, B D Barnett, H Van Mellaert
Affiliations

Mechanism of insect resistance to the microbial insecticide Bacillus thuringiensis

J Van Rie et al. Science. .

Abstract

Receptor binding studies show that resistance of a laboratory-selected Plodia interpunctella strain to a Bacillus thuringiensis insecticidal crystal protein (ICP) is correlated with a 50-fold reduction in affinity of the membrane receptor for this protein. The strain is sensitive to a second type of ICP that apparently recognizes a different receptor. Understanding the mechanism of resistance will provide strategies to prevent or delay resistance and hence prolong the usefulness of B. thuringiensis ICPs as environmentally safe insecticides.

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